Mapping实验可标测心肌组织传导速度及传导不均一性

此案例中，科研工作者发现了术后模型容易引起房颤，但未能在功能上阐述容易引起房颤发生的电生理机制，初次投稿后，被Reviewers要求补做mapping实验。
Mapping实验从电生理功能层面发现术后模型的心房电活动传导速度减慢、传导不均一性增加，这两点都是房颤发生的重要影响因素，强有力的佐证了该手术引起房颤的机理机制。

(A). A Langendorff perfused heart and 32 multi-electrode arrays was placed on the right atria. (B). Layout of 32 multi-electrode arrays.(C). representative examples of right atrium waveforms and activation during sinus rhythm from a sham rat (left) and a SP (sterile pericarditis) rat on postoperative day 3 (right) analysed by multielectrode array. In contrast to the atrial activation patterns in sham rats, the maps from SP rats were characterized by inhomogeneous conduction.

References:

Huang Z, Chen X, Qian C, et al. Signal transducer and activator of transcription 3/microRNA-21 feedback loop contributes to atrial fibrillation by promoting atrial fibrosis in a rat sterile pericarditis model[J]. Circulation: Arrhythmia and Electrophysiology, 2016, 9(7): e003396.